토끼 두개골 결손부에서 블록형과 분말형 hydroxyapatite의 골전도 효과
The effects of bone regeneration in rabbit calvarial defect with particulated and block type of hydroxyapatite
구순자, 이용근, 정의원, 최성호, 임현창, 김창성, 엄유정, 손주연,
소속 상세정보
구순자 ( Gu Sun-Ja ) - 연세대학교 치과대학 치주과학교실
이용근 ( Lee Yong-Keun ) - 연세대학교 치과대학 치과생체재료공학교실
정의원 ( Jung Ui-Won ) - 연세대학교 치과대학 치주과학교실
최성호 ( Choi Seong-Ho ) - 연세대학교 치과대학 치주과학교실
임현창 ( Lim Hyun-Chang ) - 연세대학교 치과대학 치주과학교실
김창성 ( Kim Chang-Sung ) - 연세대학교 치과대학 치주과학교실
엄유정 ( Um Yoo-Jung ) - 연세대학교 치과대학 치주과학교실
손주연 ( Sohn Joo-Yeon ) - 연세대학교 치과대학 치주과학교실
KMID : 0363020090390030321
Abstract
Purpose: The purpose of this study was to evaluate the bone regeneration of particulated hydroxyapatite(HA) and block type of hydroxyapatite graft in rabbit calvarial defects.
Methods: An 8 mm calvarial circular defects were created in sixteen young adult New Zealand white male rabbits (weight 3.0~3.5 kg). Each defects were filled with Bio-Oss, particulated HA and block type HA. Sham surgery control defects were filled with blood clots. The specimens were harvested at 4 weeks and 8 weeks for histologic and histomorphometric evaluation.
Results: Histomorphometric analysis demonstrated statistical differences in defect closure, new bone formation, and bone density of the four groups. Block type of HA group showed increased bone formation and bone density at 4 weeks and 8 weeks compared with Bio-Oss group or sham surgery control group(p<0.05).
Conclusions: Block type of HA is an effective material for osteoconduction in rabbit calvarial defects, which may acts as a guide in use of these products in human application.
키워드
bone regeneration;bone substitutes;hydroxyapatites
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